UCL School of Life and Medical Sciences



Selected images
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for large version)

Perivascular nerves of mesenteric artery.


Nitric oxide synthase (eNOS) in human brain arter.


Perivascular nerves of mesenteric artery.



Image Galleries

Vessel structure and cerebral endothelium

Endothelial vasoactive agents and receptors

Injured vessels, platelets and leukocytes

Perivascular nerves

Andrzej Loesch

Professor of Medical Sciences

Visitor to Division of Medicine
Royal Free Campus
University College London
Rowland Hill Street
London NW3 2PF, UK

Email: a.loesch@ucl.ac.uk                        aloesch@talktalk.net

Gallery 3

Injured vessels,  platelets and leukocytes

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Figure 1: Platelets in injured vessel

Injured initima of carotid artery, after balloon-angioplasty.

TEM image of injured intima of carotid artery (rat 24h after balloon-angioplasty displays no endothelial cells but clustered platelets at the artery luminal surface. Specimen was stained (black label) with lectin from Bandeirea simplicifolia (BS-I isolectin B4)



Original magnification x5000

Figure 2 (a-d): Leukocyte invasion into vascular wall

Leukocytes adhere to endothelium

TEM images of injured carotid artery (rat 4-8 weeks after balloon-angioplasty) display various stages of leukocyte migration from the vessel lumen to the neointima. Image (a) shows leukocytes adhered to regenerated endothelium. Images below show: (b) a leukocyte migrating through the endothelial layer, (c) thinned endothelium overlaying a leukocyte, (d) a leukocyte with visible nucleus is located in deeper regions of the neointima. Specimens were stained (black label) with BS-I isolectin B4; label is seen around the leukocyte surface (membrane), some is on endothelial plasmalemma.

Leukocyte migrating through endothelial layterEndothelium overlaying leukocyte Leukocyte deep in intima

Original magnifications: a x4000, b x8000, c x8000, d x4000.