Insulin receptor sequence of Homo sapiens
DEFINITION insulin receptor [Homo sapiens].
>IRHomo
MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRP
EDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNIT
RGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCW
THSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRC
VNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDS
VTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNG
DQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD
IDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPIS
VSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQS
EYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNV
TVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERG
CRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLR
KRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEA
ETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP
EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY
RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLD
RSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
Query ID :lcl|18830
The query ID is temporary, to search for conserved domains just copy the FASTA sequence from above and BLAST it.
An image of the BLAST search showing the c onserved domains :
Conserved domains: PTKc-InsR
Alignments
Snap shot of some alignments: ( 4 alignments taken)
Insulin receptor precursor [Rattus norvegicus]
Click here to view on EntrezBits: 2593 E: (0.0)
>gi|8393621|ref|NP_058767.1| insulin receptor precursor [Rattus norvegicus]MGSGRGCETTAVPLLMAVAVAGGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE DFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITR GSVRIEKNNELCYLATIDWSRILDYVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWT HSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCV NFSFCQDLHYKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSV TSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLE IGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGD QASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDI DPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPI SVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQ SEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPSRKRRSLEEVGN VTATTPTLPDFPNISSTIAPTSHEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERSGVAAY VSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALER GCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFL RKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGE VETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLR PDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY YRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPD NCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPL DRSSHCQREEAGCREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS
Insulin receptor precursor [Mus musculus]
Bits: 2577 E: (0.0)
>gi|157057178|ref|NP_034698.2| insulin receptor precursor [Mus musculus]
MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRP
EDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNIT
RGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCW
THSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRC
VNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDS
VTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNG
DQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD
IDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDP
ISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHN
QSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDF
PNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKA
DDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGN
YSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGP
LYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVN
ESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPP
PTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMR
MCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEA
GGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS
Insulin receptor precursor [Gallus gallus]
Bits: 1639 E: (0.0)
>gi|4588602|gb|AAD26153.1| insulin receptor precursor [Gallus gallus]
NIAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLHLIRGETLEAGNYSFYALDNQNLRQLWDWSKHN
LTIARGKLFFHYNPKLCLSEIHKMEEISGTKGRQERNDIALKTNGDQASCENELLKFSSIRTSHDKILLK
WEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDVDPPPRSNEPKAQAQPGWLLRGLKP
WTQYAVFVKTLVTFSDERRTYGAKSEIIYVQTNATVPSVPLDPISVSNSSSQIILKWKPPSEPNGNITHY
LVYWQQQAEDSELYELDYCLKGLKLPSRTWSPPFESEDPQKYNQSESEDVSGECCSCPKTDSQIQKELEE
SAFRKTFENYLHNEVFVPRPSRKRRDLGSIANATVVIPTIPSSPNSSAAASESAEEQKPFEKVKFKESLV
ISGLRHFTGYRIELHACNHDAQESRCSVAAYVSARTMPEAKADDIVGPVTHELVEKNTVHLKWQEPKEPN
GLIVLYEVNYGRLGEAEEAHFCVSRKHFASEQGCKLRGLQPGNYSVRIRATSLAGNGSWTEPTYFYVADY
LNAQPNIAVIIVPIIFAIIIAGIIGAAYVLVKKRQTEGPTGPLYASSNPEYLSASDVYVPDEWEVPREKI
TLLRELGQGSFGMVYEGIAKDIVKGELETRVAVKTVNESASLRERIEFLNEASVMKGFICHHVVRLLGVV
SKGQPTLVVMELMAHGDFKSYLRSLRPDAENNPGRPPPTLREMIQMAAEIADGMAYLNAKKFVHRDLAAR
NCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTYSDVWSFGVVLWEISSLA
EQPYQGLSNEQVLKFVMDGGYLDQPDNCPERLHNLMQMCWQYNPKMRPTFIEVIEMLKEDLHPSFQEVSF
FYSEENKPLETEEYEMDFENMESIPLDPSSYTQRDKALGRDNGPSMALKGNYEEHIPYTHMNGGKKDGRI
LSMPRSSPS
IGF-I receptor subtype a [Cyprinus carpio]
Click here to view on entrez
Bits: 1408 E:(0.0)
>gi|33355376|gb|AAN52151.1| IGF-I receptor subtype a [Cyprinus carpio]
MRSGTARDVWTLFWGPVLFLSTICLWSAHGEVCGPHIDIRNDISEFKKLENCTVVEGYLQILLIGDKNNN
LNQEHFRTLSFPKLTMVTDYLLLFRVSGLDSLSMLFPNLNVIRGRNLFYNYALVIFEMTSLKDIGLYNLR
NITRGAIRIEKNPELCYLDSVDWSLIMDAEFNNYIAGNKQSKECGDVCPGIMEDRPQCIRTSFNDNYSYR
CWTSNDCQKVCPKECEKRACTYKGKCCHPQCLGSCTEPDNDKACAACQHYFHEDRCVETCPQGTYKFEGW
RCITMDMCARVHLPSEVDFVIHNGECMPECPPGFTRNETQSMFCSACDGLCDKVCESKTIDSVDAAQSLQ
GCTVIKGNLNINIRRGNNIASELESFMGLIQTVTGYVKIKHSQTLGSLSFLKSLRYIHGEELTEQSYAFS
AIDNQNLQYLWDWSQHNLTIRAGKLFFRFNPKLCMSEIQKMWEKTGVKEKMEEDDARSNGERASCESYIL
KFKSNHTQSTRIKLTWERYRPPDYRDLISFIVYYKEAPFQNITEFDGQDGCGSNSWNMVDVDLPQDKSTD
PGVLLSSLKPWTQYAIFVKAVTLVVEDKHILGAKSEVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPP
ISPNGNKTFYLLRWQQQAEDRELYQHNYCSKELKIPIRISATALSDMEGETKPTKSDVGGGEKGCCPCPK
TKEDLKAEAEDRSYRKVFENFLHNSIFTPRPPDRKRRDLFGVANGTLLQGASRNITGMESNITDPKLHEK
EYPFSEDKVYTEFMEISNLQPFTVYRIDIHACNYEIHRCSAAAFVFSRTKPADKADDIPGTVTQERDEKG
EGTVLLRWPEPHHPNGLILMYEIKYRLGTEPEKHECVSRQQYRVLRGAQLSNLPSGNYSARVRATSLAGN
GSWTEPVSFYVPPPKRNYDNAFLLAIIIPIIVLLLLTAVISVVIFVTKKRNSDRLGNGVLYASVNPEYFS
PFEMYVPDEWEVAREKITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASMRERIEFLNEAS
VMKEFNCHHVVRLLGVVSQRQPTLVIMELMTRGDLKSYLRSLRSKEQGYSTQSLPPLKKMIQMASEIADG
MAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTN
SDVWSFGVVLWEIATLAKQPYQGMSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI
INSIKEELEPPFQEVSFFYSEENKPPDTEELDMEVENMENVPLEPASMLAPSSQGSTGAQTQSPQPLSPA
QGPGTPVGSAQTPSTSPPPSSSSASPGLVLDKHSGQVAANGPVLLLGPAFDETQPYAHMNGGRKNERALP
LPQSSAC
Insulin receptor of Homo sapiens
Multiple Alignments
Scores Table : the higher the score, the higher the similarity b e t w een the sequences .
E.g. the score between Homo Sapiens and Rats is 94, the score between Homo Sapiens and House mouse is 95, the score between rats and House mouse is 98 etc..
SeqA Name Len(aa) SeqB Name Len(aa) Score
=====================================================
1 Homo 1382 2 Rat 1383 94
1 Homo 1382 3 House 1372 95
1 Homo 1382 4 Chicken 989 84
1 Homo 1382 5 Fish 1407 53
2 Rat 1383 3 House 1372 98
2 Rat 1383 4 Chicken 989 83
2 Rat 1383 5 Fish 1407 54
3 Mouse 1372 4 Chicken 989 83
3 M ouse 1372 5 Fish 1407 54
4 Chicken 989 5 Fish 1407 58
=====================================================
multiple sequence alignment : (House mouse is shown as House in the multiple sequence alignment ) Rat MGSGRGCETTAVPLLMAVAVAG-GTAGHLYPGEVC-PGMDIRNNLTRLHELENCSVIEGH House MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVC-PGMDIRNNLTRLHELENCSVIEGH Homo MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVC-PGMDIRNNLTRLHELENCSVIEGH Chicken ------------------------------------------------------------ Fish --MRSGTARDVWTLFWGPVLFLSTICLWSAHGEVCGPHIDIRNDISEFKKLENCTVVEGY Rat LQILLMFKTR----PEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLF House LQILLMFKTR----PEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLF Homo LQILLMFKTR----PEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLF Chicken ------------------------------------------------------------ Fish LQILLIGDKNNNLNQEHFRTLSFPKLTMVTDYLLLFRVSGLDSLSMLFPNLNVIRGRNLF Rat FNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDYVEDNYIVLN House FNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLN Homo FNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLN Chicken ------------------------------------------------------------ Fish YNYALVIFEMTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVDWSLIMDAEFNNYIAGN Rat KDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC House KDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC Homo KDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC Chicken ------------------------------------------------------------ Fish KQ-SKECGDVCPGIMEDRPQCIRTSFNDNYSYRCWTSNDCQKVCPKECEKRACTYKGKCC Rat HKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHYKCRN House HKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRN Homo HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKN Chicken ------------------------------------------------------------ Fish HPQCLGSCTEPDNDKACAACQHYFHEDRCVETCPQGTYKFEGWRCITMDMCARVHLPSEV Rat SRKPGCHQYVIHNNKCIPECPSGYTMNSSN-LMCTPCLGPCPKVCQILEGEKTIDSVTSA House SRKPGCHQYVIHNNKCIPECPSGYTMNSSN-LMCTPCLGPCPKVCQILEGEKTIDSVTSA Homo SRRQGCHQYVIHNNKCIPECPSGYTMNSSN-LLCTPCLGPCPKVCHLLEGEKTIDSVTSA Chicken ------------------------------------------------------------ Fish D-------FVIHNGECMPECPPGFTRNETQSMFCSACDGLCDKVCES----KTIDSVDAA Rat QELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHL House QELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHL
Homo QELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRL Chicken ---------------------NIAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLHL Fish QSLQGCTVIKGNLNINIRRGNNIASELESFMGLIQTVTGYVKIKHSQTLGSLSFLKSLRY *:*:***: :***: ::*::**::* :* ****::.*: Rat IRGETLEIGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSG House IRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSG Homo IRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSG Chicken IRGETLEAGNYSFYALDNQNLRQLWDWSKHNLTIARGKLFFHYNPKLCLSEIHKMEEISG Fish IHGEELTEQSYAFSAIDNQNLQYLWDWSQHNLTIRAGKLFFRFNPKLCMSEIQKMWEKTG *:** * .*:* *:*****: ****.:***** *****::*****:***:** * :* Rat TKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFY House TKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFY Homo TKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFY Chicken TKGRQERNDIALKTNGDQASCENELLKFSSIRTSHDKILLKWEPYWPPDFRDLLGFMLFY Fish VKEKMEEDD--ARSNGERASCESYILKFKSNHTQSTRIKLTWERYRPPDYRDLISFIVYY .* : *.:* ::**::****. :***. :*. :* * ** * ***:***:.*:::* Rat KEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIF House KEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIF Homo KEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQN--HPGWLMRGLKPWTQYAIF Chicken KEAPYQNVTEFDGQDACGSNSWTVVDVDPPPRSNEPKAQA--QPGWLLRGLKPWTQYAVF Fish KEAPFQNITEFDGQDGCGSNSWNMVDVDLPQDKST-------DPGVLLSSLKPWTQYAIF ****:**:*******.******.:**:* * .. .** *: .********:* Rat VKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNI House VKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNI Homo VKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNI Chicken VKTLVTFSDERRTYGAKSEIIYVQTNATVPSVPLDPISVSNSSSQIILKWKPPSEPNGNI Fish VKAVTLVVEDKHILGAKSEVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPPISPNGNK **::. . :::: ****:::*::*:*: **:***. : :****.:::**.** .**** Rat THYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDD-SQKHNQSEYDDSASECCS House THYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDD-SQKHNQSEYDDSASECCS Homo THYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESED-SQKHNQSEYEDSAGECCS Chicken THYLVYWQQQAEDSELYELDYCLKGLKLPSRTWSPPFESED-PQKYNQSESEDVSGECCS Fish TFYLLRWQQQAEDRELYQHNYCSKELKIPIRISATALSDMEGETKPTKSDVGGGEKGCCP *.**: *::**** **:: :** * **:* * :..:.. : * .:*: . **. Rat CPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPSRKRRSLEEVGNVT House CPKTDSQILKELEESSFRKTFEDYLHNVVFVP------------RPSRKRRSLEEVGNVT Homo CPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVT Chicken CPKTDSQIQKELEESAFRKTFENYLHNEVFVP------------RPSRKRRDLGSIANAT Fish CPKTKEDLKAEAEDRSYRKVFENFLHNSIFTPR-----------PPDRKRRDLFGVANGT ****..:: * *: ::**.**::*** :*.* *.****.* :.* * Rat ATTPTLPDFPNISSTIAP-TSHEEHRPF-EKVVNKESLVISGLRHFTGYRIELQACNQDS House ATTLTLPDFPNVSSTIVP-TSQEEHRPF-EKVVNKESLVISGLRHFTGYRIELQACNQDS Homo VAVPTVAAFPNTSSTSVP-TSPEEHRPF-EKVVNKESLVISGLRHFTGYRIELQACNQDT Chicken VVIPTIPSSPN-SSAAAS-ESAEEQKPF-EKVKFKESLVISGLRHFTGYRIELHACNHDA Fish LLQGASRNITGMESNITDPKLHEKEYPFSEDKVYTEFMEISNLQPFTVYRIDIHACNYEI : .. .* . *:. ** *. .* : **.*: ** ***:::*** : Rat PEERSGVAAYVSARTMPEAKADDIVGPVTHEIFENN--VVHLMWQEPKEPNGLIVLYEVS House PDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENN--VVHLMWQEPKEPNGLIVLYEVS Homo PEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENN--VVHLMWQEPKEPNGLIVLYEVS Chicken QESRCSVAAYVSARTMPEAKADDIVGPVTHELVEKN--TVHLKWQEPKEPNGLIVLYEVN Fish H--RCSAAAFVFSRTKPADKADDIPGTVTQERDEKGEGTVLLRWPEPHHPNGLILMYEIK *...**:* :** * ***** *.**:* *:. .* * * **:.*****::**:.
Rat YRRYGD-EELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVT- House YRRYGD-EELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVT- Homo YRRYGD-EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVT- Chicken YGRLGEAEEAHFCVSRKHFASEQGCKLRGLQPGNYSVRIRATSLAGNGSWTEPTYFYVA- Fish YR-LGTEPEKHECVSRQQYRVLRGAQLSNLPSGNYSARVRATSLAGNGSWTEPVSFYVPP * * * * ****::: :*.:* .* .****.*:**************. ***. Rat DYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGP-MGPLYASSNPEYLSASD House DYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGP-MGPLYASSNPEYLSASD Homo DYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGP-LGPLYASSNPEYLSASD Chicken DYLNAQPNIAVIIV-PIIFAIIIAGIIGAAYVLVKKRQTEGP-TGPLYASSNPEYLSASD Fish PKRNYDNAFLLAIIIPIIVLLLLTAVISVVIFVTKKRNSDRLGNGVLYASVNPEYFSPFE : : *: *:*. :::: :*. .. :**:.: * **** ****:*. : Rat VFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESAS House VFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESAS Homo VFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESAS Chicken VY-----VPDEWEVPREKITLLRELGQGSFGMVYEGIAKDIVKGELETRVAVKTVNESAS Fish MY-----VPDEWEVAREKITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESAS :: *******.*****: ************** *:.::*.* *****:******** Rat LRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAEN House LRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAEN Homo LRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN Chicken LRERIEFLNEASVMKGFICHHVVRLLGVVSKGQPTLVVMELMAHGDFKSYLRSLRPDAEN Fish MRERIEFLNEASVMKEFNCHHVVRLLGVVSQRQPTLVIMELMTRGDLKSYLRSLRSKEQG :************** * ************: *****:****::**:**:*****.. :. Rat NPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI House NPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI Homo NPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI Chicken NPGRPPPTLREMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI Fish YSTQSLPPLKKMIQMASEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI . :. *.*::****::***********:***************.*************** Rat YETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQ House YETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQ Homo YETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQ Chicken YETDYYRKGGKGLLPVRWMAPESLKDGVFTTYSDVWSFGVVLWEISSLAEQPYQGLSNEQ Fish YETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAKQPYQGMSNEQ *******************:**********: **:**********::**:*****:**** Rat VLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF House VLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF Homo VLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF Chicken VLKFVMDGGYLDQPDNCPERLHNLMQMCWQYNPKMRPTFIEVIEMLKEDLHPSFQEVSFF Fish VLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIINSIKEELEPPFQEVSFF **:***:** ** *****: : :**:****:******:*:*::: :*::*.*.* ***** Rat YSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGCR--------------------- House YSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGR--------------------- Homo HSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGR--------------------- Chicken YSEENKPLETEEYEMDFENMESIPLDPSSYTQRDKALGR--------------------- Fish YSEENKPPDTEELDMEVENMENVPLEPASMLAPSSQGSTGAQTQSPQPLSPAQGPGTPVG :*****. ::** :*:.*:**.:**: :* .. Rat ------------------------------EGGSSLSIKRTYDEHIPYTHMNGGKKNGRV House ------------------------------EGGSSLSIKRTYDEHIPYTHMNGGKKNGRV Homo ------------------------------DGGSSLGFKRSYEEHIPYTHMNGGKKNGRI Chicken ------------------------------DNGPSMALKGNYEEHIPYTHMNGGKKDGRI Fish SAQTPSTSPPPSSSSASPGLVLDKHSGQVAANGPVLLLGPAFDETQPYAHMNGGRKNERA .*. : : ::* **:*****:*: * Rat LTLPRSNPS House LTLPRSNPS Homo LTLPRSNPS Chicken LSMPRSSPS Fish LPLPQSSAC *.:*:*...