banner image for macmillan group

Publications

  1. Adams, A.; Cowper, B.; Morgan, R.E.; Premdjee, B.; Caddick, S.; Macmillan, D. Cysteine Promoted C-Terminal Hydrazinolysis of Native Peptides and Proteins Angew. Chem. Int. Ed. 2013, 52, 13062-13066.

  2. Currie, S.M.; Findlay, E. G.; McHugh, B.; Mackellar, A.; Man, T.; Macmillan, D.; Wang, H.; Fitch, P.; Schwarze, J.; Davidson, D.J. The human cathelicidin LL-37 has antiviral activity against Respiratory Syncytial Virus.  PLoS ONE, 2013, 8, e73659.

  3. Cowper, B.; Craik, D.; Macmillan, D. Cowper, B., et al. (2013). "Making Ends Meet: Chemically Mediated Circularization of Recombinant Proteins." Chembiochem 2013, 14(7): 809-812.

  4. Adams, A.L.; Macmillan, D. Investigation of Peptide Thioester Formation via N®Se Acyl Transfer.  J. Peptide Sci. 2013, 19(2): 65-73.

  5. Harvey, S.; Porrini, M.; Stachl, C.; Macmillan, D.; Zinzalla, G.; Barran, P. Small Molecule Inhibition of c-MYC:MAX leucine zipper for-mation is revealed by Ion Mobility Mass Spectrometry. J. Am. Chem. Soc. 2012, 134(47): 19384-19392.

  6. Jungmichel, S.; Clapperton, J.A.; Lloyd, J.; Spycher, C.; Pavic, L.; Li, J.; Haire, L.F.; Bonalli, M.; Lukas, C.; Lukas, J.; MacMillan, D.; Stucki, M.; Smerdon, S.J. The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.  Nucleic Acids Res.  2012, 40 (9). 3913–3928.

  7. K. Hirano, M. Izumi, D. Macmillan, K. Tezuka, T. Tsuji, Y. Kajihara.  Semisynthesis of Erythropoietin Analogue Having Three Oligosaccharides J. Carbohyd. Chem. 2011, 30, 306-319.

  8. Y. Kajihara, M. Izumi, K. Hirano, T. Murase, D. Macmillan, R. Okamoto, Elucidating the Function of Complex-Type Oligosaccharides by Use of Chemical Synthesis of Homogeneous Glycoproteins, Isr. J. Chem. (special issue on Chemical Protein Synthesis), 2011, 51, 917-929.

  9. D. Macmillan, A. Adams, B. Premdjee, Shifting Native Chemical Ligation into Reverse through N→S Acyl Transfer, Isr. J. Chem. (special issue on Chemical Protein Synthesis) ,2011, 51, 885-899.

  10. B. Premdjee, A. L. Adams, D. Macmillan, Native N-glycopeptide thioester synthesis through N®S acyl transfer, Bioorg. Med. Chem. Lett. 2011, 21, 4973-4975.

  11. D. Macmillan, M. De Cecco, N. L. Reynolds, L. F. A. Santos, P. E. Barran, J. R. Dorin, Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement, Chembiochem 2011, 12, 2133-2136.

  12. Richardson, J.P.; Macmillan, D. Semi-Synthesis of glycoproteins from E. coli through native chemical ligation. Meth. Mol. Biol. 2011, 705, 151-174.

  13. Masania, J.; Li, J.; Smerdon, S.J. and Macmillan, D. Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer. Org. Biomol. Chem. 2010, 8, 5113-5119.

  14. Ackrill, T.; Anderson, D. W.; Macmillan D.  Towards biomolecular assembly employing Extended Native Chemical Ligation in combination with thioester synthesis using an N→S acyl shift. Protein Science-Biopolymers 2010 94(4), 495-503.

  15. Kang, J.; Macmillan D. Protein thioester synthesis via an N-S acyl shift. Org. Biomol. Chem. 2010, 8, 1993-2002.

  16. De Cecco, M., Seo, E.S., Clarke, D.J., McCullough, B.J., Taylor, K., Macmillan, D., Dorin, J.R., Campopiano, D.J., and Barran, P.E., Conformational Preferences of Linear b-defensins are Revealed by Ion Mobility-Mass Spectrometry. J. Phys Chem. B, 2010, 114(6), 2312-2318.

  17. McCullough, B.J.; Kalapothakis, J.M.; Chin, W.; Taylor, K.; Clarke, D.J.; Eastwood, H.; Campopiano, D.; MacMillan, D.; Dorin, J.; Barran, P.E. Binding a Heparin Derived Disaccharide to Defensin Inspired Peptides: Insights to Antimicrobial Inhibition from Gas Phase Measurements.  Phys. Chem. Chem. Phys. 2010, 12, 3589-3596.

  18. Tyrrell, C., De Cecco, M., Reynolds, N. L., Kilanowski, F., Campopiano, D., Barran, P., Macmillan, D. and Dorin, J.R.  Isoleucine/leucine2 is essential for chemoattractant activity of β-defensin Defb14 through chemokine receptor 6. Mol. Immunol. 2010, 47, 1378-1382.

  19. Richardson, J.P.; Chan, C-H.; Blanc, J.; Saadi, M.; Macmillan D. Towards semi-synthetic glycoprotein mimics:  Widening the application of peptide thioester synthesis employing N→S acyl transfer. 2010, Org. Biomol. Chem. 8, 1351-1360.

  20. Tyrrell, C., De Cecco, M., Reynolds, N. L., Kilanowski, F., Campopiano, D., Barran, P., Macmillan, D. and Dorin, J.R. Peptide Fragments of a ß-Defensin Derivative With Potent Bactericidal Activity.  Antimicrob. Agents Chemother. 2010, 54(5), 1922-1929.

  21. Virdee, S.; Macmillan, D.; Waksman, G. Semisynthetic Src SH2 Domains Demonstrate Altered Phosphopeptide Specifity by Incorporation of Unnatural Amino Acids. Chem. Biol. 2010, 17, 274-284.

  22. Richardson, J.P.; Macmillan, D. Semi-Synthesis of glycoproteins from E. coli through native chemical ligation. Meth. Mol. Biol. 2010, in press.

  23. Kang, J.; Reynolds, N.L.; Tyrrell, C.; Dorin, J.R.; and Macmillan, D.  Peptide thioester synthesis through N→S acyl-transfer:  Application to the synthesis of a b-Defensin. Org. Biomol. Chem. 2009, 7, 4918-4923.

  24. Hirano, K.; Macmillan, D.; Tezuka, K.; Tsuji, T.; Kajihara, Y. Design and synthesis of a homogeneous erythropoietin analogue having two human complex type sialyloligosaccharides by combined use of chemical and bacterial protein expression methods. Angew. Chem. Int. Ed. 2009, 48, 9557-9560.

  25. Taylor, K.; Rolfe, M.; Kilanowski, F.; Pathania, U.; Reynolds, N.; Clarke, D.; Yang, D.; Oppenheim, J.; Samuel, K.; Howie, S.; Barran, P.; MacMillan, D.; Campopiano, D.; Dorin, J. Defr1 is allelic to Defb8 and is chemoattractant for dendritic cells and CD4 T cells but does not act through chemokine receptor 6. Eur. J. Immunol. 2009, 39(5), 1353-1360. 

  26. Macmillan, D.  2, 3, 4-Trimethoxy-6-[[(4-methoxyphenyl)methyl]thio] benzaldehyde, eEROS, 2009, DOI: 10.1002/047084289X.rn00970.

  27. Kang, J.; Richardson, J.P.; Macmillan, D. 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters, Chem. Commun. 2009 (4), 407-409.

  28. Richardson, J.P.; Macmillan, D. Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation.  Org. Biomol. Chem. 2008, 6, 3977 - 3982.

  29. Marchesan, S.; Macmillan D. Chemoenzymatic Synthesis of GDP-Azidodeoxymannoses: Probes for Mannosyltransferase Activity. Chem. Commun. 2008, 4321 – 4323.

  30. Li, J.; Taylor, I.A.; Lloyd, J.; Clapperton, J.A. Howell, S.; Macmillan, D.; Smerdon, S.J.  Chk2 Oligomerisation Studied by Phosphopeptide Ligation: Implications for Regulation and Phosphodependant Interactions. J. Biol. Chem. 2008,283 (51) 36019-36030.

  31. McCullough, B.; Kalapothakis, J.; Eastwood, H.; Kemper, P.; Macmillan, D.; Dorin, J.; Taylor, K.; Barran, P.,  Development of an Ion Mobility Quadrupole Time of Flight Mass Spectrometer  - The MoQTOF, Anal. Chem. 2008, 80(16), 6336-6344.

  32. Kärkkäinen, T.S.; Kartha, K. P. R.; MacMillan D.; Field, R.A. Iodine-mediated glycosylation en route to mucin-related glyco-aminoacids and glycopeptides, Carbohydrate Res., 2008, 343, 1830-1834.

  33. Macmillan, D.; Richardson, J.P.  Mucin-Based Vaccines, Fraser-Reid Ed. Glycoscience 2008, 2645-2698.

  34. Taylor, K.; Clarke, D. J.; McCullough, B.; Chin, W.; Seo, E.; Yang, D.; Oppenheim, J.; Uhrin, D.; Govan, J. R. W.; Campopiano, D. J.; MacMillan, D.; Barran, P.; Dorin, J. R., Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3. J. Biol. Chem. 2008, 283, (11), 6631-6639.

  35. Macmillan, D.  Method of covalently linking a carbohydrate or polyalkylene oxide to a peptide, precursors for use in the method and resultant products. PCT Int. Appl. 2008, 102pp. CODEN:PIXXD2; WO2008001109.

  36. Macmillan, D. Evolving strategies for protein synthesis converge on native chemical ligation.  Angew. Chem. Int. Ed. 2006, 45, 7668-7672.

  37. Macmillan D.; Blanc, J.  A novel neoglycopeptide linkage compatible with native chemical ligation, Org. Biomol. Chem. 2006, 4(15), 2847-2850.

  38. Bloom, J.D.; Meinhold, P.; Meyer, M.M.; Otey, C.R.; Macmillan, D.; Arnold, F.H.  Evolving Strategies for Enzyme Engineering, Curr. Opin Struct. Biol.  2005, 15, 447-452.

  39. Shirran, S.; Garnaud, P.; Daff, S.; MacMillan, D.; Barran, P. The formation of a complex between calmodulin and neuronal nitric oxide synthase is determined by ESI-MS. Journal of the Royal Society, Interface, 2005, 2, 465 - 476.

  40. Macmillan, D.; Anderson D.W.  Rapid synthesis of acyltransfer auxiliaries for cysteine-free Native Glycopetide Ligation.  Org. Lett. 2004, 6(25), 4659-4662. 

  41. Macmillan, D.; Arham, L. Cyanogen Bromide Cleavage Generates Fragments Suitable for Expressed Protein and Glycoprotein Ligation. J. Am. Chem. Soc. 2004, 124, 9530-9531.

  42. Macmillan, D.; Bertozzi, C. R.  Modular Assembly of Glycoproteins: Towards the Synthesis of GlyCAM-1 by using Expressed Protein Ligation. Angew. Chem. Int. Ed.  2004, 43, 1355-1359.

  43. Macmillan, D.; Daines, A. M. Recent developments in the synthesis and discovery of oligosaccharides and glycoconjugates for the treatment of disease. Curr. Med. Chem.  2003, 10, 2733-2773.

  44. Macmillan, D.; Daines, A. M.; Bayrhuber, M.; Flitsch, S. L.  Solid-Phase Synthesis of Thioether-Linked Glycopeptide Mimics for Application to Glycoprotein Semi-synthesis. Org. Lett.  2002, 4, 1467-1470.

  45. Macmillan, D., Bill, R. M., Sage, K. A., Fern, D. & Flitsch, S. L. Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin. Chem. Biol.  2001, 8, 133-145.

  46. Macmillan, D. & Bertozzi, C. R. New directions in glycoprotein engineering. Tetrahedron 2000, 56, 9515-9525.