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Publications

  1. Richardson, J.P.; Saadi, M.; Blanc, J.; Macmillan D. Sequential chemoselective ligations in the assembly of erythropoietin mimics. 2009, in preparation.

  2. McCullough, B.; Kalapothakis, J.; Chin, W.; Taylor, K.; Clarke, D.;Eastwood, H.; Campopiano, D.; Dorin, J.; MacMillan, D.; Barran, P. Binding a Heparin Derived Disaccharide to Defensin Inspired Peptides: Insights to Antimicrobial Inhibition from Gas Phase Measurements, 2009, Submitted.

  3. Richardson, J.P.; Macmillan, D. Semi-Synthesis of glycoproteins from E. coli through native chemical ligation. Meth. Mol. Biol. 2009, submitted.

  4. Taylor, K.; Rolfe, M.; Kilanowski, F.; Pathania, U.; Reynolds, N.; Clarke, D.; Yang, D.; Oppenheim, J.; Samuel, K.; Howie, S.; Barran, P.; MacMillan, D.; Campopiano, D.; Dorin, J. Defr1 is allelic to Defb8 and is chemoattractant for dendritic cells and CD4 T cells but does not act through chemokine receptor 6. Eur. J. Immunol. 2009, in press.

  5. Macmillan, D. 2, 3, 4-Trimethoxy-6-[[(4-methoxyphenyl)methyl]thio] benzaldehyde, eEROS, 2009, in press.

  6. Kang, J.; Richardson, J.P.; Macmillan, D. 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters, Chem. Commun. 2009 (4), 407-409.

  7. Richardson, J.P.; Macmillan, D. Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation.  Org. Biomol. Chem. 2008, 6, 3977 - 3982.

  8. Marchesan, S.; Macmillan D. Chemoenzymatic Synthesis of GDP-Azidodeoxymannoses: Probes for Mannosyltransferase Activity. Chem. Commun. 2008, 4321 – 4323.

  9. Li, J.; Taylor, I.A.; Lloyd, J.; Clapperton, J.A. Howell, S.; Macmillan, D.; Smerdon, S.J.  Chk2 Oligomerisation Studied by Phosphopeptide Ligation: Implications for Regulation and Phosphodependant Interactions. J. Biol. Chem. 2008,283 (51) 36019-36030.

  10. McCullough, B.; Kalapothakis, J.; Eastwood, H.; Kemper, P.; Macmillan, D.; Dorin, J.; Taylor, K.; Barran, P.,  Development of an Ion Mobility Quadrupole Time of Flight Mass Spectrometer - The MoQTOF, Anal. Chem. 2008, 80(16), 6336-6344.

  11. Kärkkäinen, T.S.; Kartha, K. P. R.; MacMillan D.; Field, R.A. Iodine-mediated glycosylation en route to mucin-related glyco-aminoacids and glycopeptides, Carbohydrate Res., 2008, 343, 1830-1834.

  12. Macmillan, D.; Richardson, J.P.  Mucin-Based Vaccines, Fraser-Reid Ed. Glycoscience 2008, 2645-2698.

  13. Taylor, K.; Clarke, D. J.; McCullough, B.; Chin, W.; Seo, E.; Yang, D.; Oppenheim, J.; Uhrin, D.; Govan, J. R. W.; Campopiano, D. J.; MacMillan, D.; Barran, P.; Dorin, J. R., Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3. J. Biol. Chem. 2008, 283, (11), 6631-6639.

  14. Macmillan, D.  Method of covalently linking a carbohydrate or polyalkylene oxide to a peptide, precursors for use in the method and resultant products. PCT Int. Appl. 2008, 102pp. CODEN:PIXXD2; WO2008001109.

  15. Macmillan, D. Evolving strategies for protein synthesis converge on native chemical ligation.  Angew. Chem. Int. Ed. 2006, 45, 7668-7672.

  16. Macmillan D.; Blanc, J.  A novel neoglycopeptide linkage compatible with native chemical ligation, Org. Biomol. Chem. 2006, 4(15), 2847-2850.

  17. Bloom, J.D.; Meinhold, P.; Meyer, M.M.; Otey, C.R.; Macmillan, D.; Arnold, F.H.  Evolving Strategies for Enzyme Engineering, Curr. Opin Struct. Biol.  2005, 15, 447-452.

  18. Shirran, S.; Garnaud, P.; Daff, S.; MacMillan, D.; Barran, P. The formation of a complex between calmodulin and neuronal nitric oxide synthase is determined by ESI-MS. Journal of the Royal Society, Interface, 2005, 2, 465 - 476.

  19. Macmillan, D.; Anderson D.W.  Rapid synthesis of acyltransfer auxiliaries for cysteine-free Native Glycopetide Ligation.  Org. Lett. 2004, 6(25), 4659-4662. 

  20. Macmillan, D.; Arham, L. Cyanogen Bromide Cleavage Generates Fragments Suitable for Expressed Protein and Glycoprotein Ligation. J. Am. Chem. Soc. 2004, 124, 9530-9531.

  21. Macmillan, D.; Bertozzi, C. R. Modular Assembly of Glycoproteins: Towards the Synthesis of GlyCAM-1 by using Expressed Protein Ligation. Angew. Chem. Int. Ed.  2004, 43, 1355-1359.

  22. Macmillan, D.; Daines, A. M. Recent developments in the synthesis and discovery of oligosaccharides and glycoconjugates for the treatment of disease. Curr. Med. Chem. 2003, 10, 2733-2773.

  23. Macmillan, D.; Daines, A. M.; Bayrhuber, M.; Flitsch, S. L. Solid-Phase Synthesis of Thioether-Linked Glycopeptide Mimics for Application to Glycoprotein Semi-synthesis. Org. Lett. 2002, 4, 1467-1470.

  24. Macmillan, D., Bill, R. M., Sage, K. A., Fern, D. & Flitsch, S. L. Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin. Chem. Biol. 2001, 8, 133-145.

  25. Macmillan, D. & Bertozzi, C. R. New directions in glycoprotein engineering. Tetrahedron 2000, 56, 9515-9525.