Macmillan group, UCL

Welcome to the Macmillan group website

The Macmillan group is actively engaged in the semi-synthesis of modified proteins. Protein synthesis and semi synthesis will be important in unravelling the mechanisms of action of processes involving post-translationally modified (glycosylated, phosphorylated) proteins since such processes are not template driven and not under direct genetic control. This endeavour makes use of synthetic organic chemistry, molecular biology, protein expression and protein engineering. Other projects include glycosyltransferase engineering, antimicrobial peptide synthesis, and synthesis and utility of transition metal complexes. The Macmillan group is based within the Department of Chemistry, UCL.