CLUSTAL 2.0.10 multiple sequence alignment HUMAN Adenylate cyclase ADCY1-10 Type 1-10 http://www.ebi.ac.uk/Tools/es/cgi-bin/jobresults.cgi/clustalw2/clustalw2-20090324-22580162.aln? 2type2 ------------------------------------------------------------ 4type4 ------------------------------------------------------------ 7type7 ------------------------------------------------------------ 5type5 ----MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKK 6type6 ----MSWFSGLLVP-------------KVDERKTAWGERNGQKR---------SRRRGTR 1type1 ----MAGAP---------------------------------------------RGGGGG 8type8 ----MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRG 3type3 ---------------------------------------------------------MPR 9type9 ---------------------------MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKIN 10type10 MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSS 2type2 ------------------------------------------------------------ 4type4 ------------------------------------------------------------ 7type7 ------------------------------------------------------------ 5type5 PGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSR 6type6 AGGFCTP----RYMSCLRDAEPPSPTPAGP------------PRCPWQD---------DA 1type1 GGGAGEP----------------------------------------------------- 8type8 GSGSGSGGSGKASDPAGGGPNHHAPQLSGD------------SALPLYS----------- 3type3 NQGFSEPEYSAEYSAEYSVSLPSDPDRGVG------------------------------ 9type9 PKQLSSNSHPKHCKYSISSSCSSSGDSGGVP----------------------------- 10type10 AMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVI 2type2 ------------------------------------------------------------ 4type4 ------------------------------------------------------------ 7type7 ------------------------------------------------------------ 5type5 RQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAG 6type6 FIRRGGP----------------------GKGKELGLRAVALGFEDT------------- 1type1 ------------------------------GGAER------------------------- 8type8 ----------------------------LGPGERAHSTCGTKVFPERSGSG--------- 3type3 ------------------------------------------------------------ 9type9 ------------------------------------------------------------ 10type10 KCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQN 2type2 -----MWQEAMRRRRYLRDRSEEAA------------------GGGDGLPRSRDWLYESY 4type4 ------------MARLFSPRP----------------------------PPSEDLFYETY 7type7 ---------MPAKGRYFLNEGEE--------------------------GPDQDALYEKY 5type5 AVEGGEGSGDGGSSADSGSGAGPGA---VLSLGACCLALLQIFRSKKFPSDKLERLYQRY 6type6 -----EVTTTAGGTAEVAPDAVP------RSGRSCWRRLVQVFQSKQFRSAKLERLYQRY 1type1 ---------AAGTSRRRGLRACD----------------------EEFACPELEALFRGY 8type8 ---SASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRY 3type3 -------RTHEISVRNSGSCLCLPR-----------------FMRLTFVPESLENLYQTY 9type9 -----RRVGGGGRLRRQKKLPQLFER-----------ASSRWWDPKFDSVNLEEACLERC 10type10 MAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYY . 2type2 YCMSQQHP-LIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILV 4type4 YSLSQQYP-LLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLA 7type7 QLTSQHGP-LLLTLLLVAATACVALIIIAFSQG-DPSRHQAILGMAFLVLAVFAALSVLM 5type5 FFRLNQSS--LTMLMAVLVLVC--LVMLAFHAARP-PLQLPYLAVLAAAVGVILIMAVLC 6type6 FFQMNQSS--LTLLMAVLVLLT--AVLLAFHAAPA-RPQPAYVALLACAAALFVGLMVVC 1type1 TLRLEQAA--TLKALAVLSLLAGALALAELLGAPG-PAPGLAKGSHPVHCVLFLALLVVT 8type8 FLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVR 3type3 FKRQRHET-----LLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVL 9type9 FPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLY 10type10 PSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLM .: : : : 2type2 CIESVFKKLLRLFSLVIWICLVAMGYLFMCFGG---------------TVSPWDQVSFFL 4type4 SREQRLQRWTRPLSGLVWVALLALGHAFLFTGG---------------VVSAWDQVSYFL 7type7 YVECLLRRWLRALALLTWACLVALGYVLVFDAWT-------------KAACAWEQVPFFL 5type5 NRAAFHQ------DHMGLACYALIAVVLAVQVVG---------LLLPQPRSASEGIWWTV 6type6 NRHSFRQ------DSMWVVSYVVLGILAAVQVGG---------ALAADPRSPSAGLWCPV 1type1 NVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPA--RGSAGAAGGPATAEQGVWQLL 8type8 KDTTSHT----YLQYSGVVTWVAMTTQILAAGLG--------------YGLLGDGIGYVL 3type3 CKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLN-----------FARAHAASDTVGWQV 9type9 ARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCI 10type10 FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELT 2type2 FIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEH---LVWQILANVIIF 4type4 FVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPA---LLPQLAANAVLF 7type7 FIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVR---VGLQLLANAVIF 5type5 FFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTN----AQDQF---LLKQLVSNVLIF 6type6 FFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLN----RGDAF---LWKQLGANVLLF 1type1 LVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVP---AKRPR---LWRTLGANALLF 8type8 FTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIP----RLAVI---SINQVVAQAVLF 3type3 FFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLY 9type9 EVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLH 10type10 HALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMY : . . : :. .:. 2type2 ICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIK----LEFEKRQQERLLLSLLPAHIAM 4type4 LCGNVAGVYHKALMERALRATFREALSSLHSRRR----LDTEKKHQEHLLLSILPAYLAR 7type7 LCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRK----LRIEKRQQENLLLSVLPAHISM 5type5 SCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH----SQRENQQQERLLLSVLPRHVAM 6type6 LCTNVIGICTHYPAEVSQRQAFQETRGYIQARLH----LQHENRQQERLLLSVLPQHVAM 1type1 VGVNMYGVFVRILTERSQRKAFLQARSCIEDRLR----LEDENEKQERLLMSLLPRNVAM 8type8 MCMNTAGIFISYLSDRAQRQAFLETRRCVEARLR----LETENQRQERLVLSVLPRFVVL 3type3 LCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMN----LEEQSQQQENLMLSILPKHVAD 9type9 GCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKD----LEVEKALKERMIHSVMPRIIAD 10type10 YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNR . : : *.:: .: 2type2 EMKAEIIQRLQGPKAGQME-----------------------NTNNFHNLYVKRHTNVSI 4type4 EMKAEIMARLQAGQGSRPE-----------------------STNNFHSLYVKRHQGVSV 7type7 GMKLAIIERLKEHGDRRCM-----------------------PDNNFHSLYVKRHQNVSI 5type5 EMKADINAKQED--------------------------------MMFHKIYIQKHDNVSI 6type6 EMKEDINTKKED--------------------------------MMFHKIYIQKHDNVSI 1type1 EMKEDF-LKPPE--------------------------------RIFHKIYIQRHDNVSI 8type8 EMINDMTNVEDEH-----------------------------LQHQFHRIYIHRYENVSI 3type3 EMLKDMKKDESQK-----------------------------DQQQFNTMYMYRHENVSI 9type9 DLMKQGDEESENSVKRHATSSPKNRKKKS---------SIQKAPIAFRPFKMQQIEEVSI 10type10 KEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRI :. : : : 2type2 LYADIVGFTRLASDCSPGELVHMLN--ELFGKFDQIAKENECMRIKILGDCYYCVS---- 4type4 LYADIVGFTRLASECSPKELVLMLN--ELFGKFDQIAKEHECMRIKILGDCYYCVS---- 7type7 LYADIVGFTQLASDCSPKELVVVLN--ELFGKFDQIAKANECMRIKILGDCYYCVS---- 5type5 LFADIEGFTSLASQCTAQELVMTLN--ELFARFDKLAAENHCLRIKILGDCYYCVS---- 6type6 LFADIEGFTSLASQCTAQELVMTLN--ELFARFDKLAAENHCLRIKILGDCYYCVS---- 1type1 LFADIVGFTGLASQCTAQELVKLLN--ELFGKFDELATENHCRRIKILGDCYYCVS---- 8type8 LFADVKGFTNLSTTLSAQELVRMLN--ELFARFDRLAHEHHCLRIKILGDCYYCVS---- 3type3 LFADIVGFTQLSSACSAQELVKLLN--ELFARFDKLAAKYHQLRIKILGDCYYCIC---- 9type9 LFADIVGFTKMSANKSAHALVGLLN--DLFGRFDRLCEETKCEKISTLGDCYYCVA---- 10type10 IAISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIF : .: :: : : :: : : ::.. . :. *.: :**: 2type2 ------GLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQ 4type4 ------GLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQ 7type7 ------GLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLR 5type5 ------GLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 6type6 ------GLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 1type1 ------GLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLR 8type8 ------GLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLR 3type3 ------GLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQK 9type9 ------GCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMR 10type10 HVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKL . : : : : . . : . . . . .: 2type2 KWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEG--------------- 4type4 KWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDA--------------- 7type7 KWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDG--------------- 5type5 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG--------------- 6type6 KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPG--------------- 1type1 KWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPG--------------- 8type8 KWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEG--------------- 3type3 RWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPG--------------- 9type9 RFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQL 10type10 IRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVVGAVQPNDISNKICLDLN------ :: . . . : . * : : 2type2 -----------DGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFR-PRHTLDGAKMR--- 4type4 -----------GMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMR--- 7type7 -----------HGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMR--- 5type5 -----------CGGERNAYLKEHSIETFLILR--CTQKRKEEKAMIAKMNRQR------- 6type6 -----------RGGERNAYLKEQHIETFLILG--ASQKRKEEKAMLAKLQRTR------- 1type1 -----------YGHERNSFLKTHNIETFFIVP--SHRRKIFPGLILSDIKPAKRMKFKTV 8type8 -----------HGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRR----- 3type3 -----------DGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPAS-- 9type9 KGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKT 10type10 --------VSCISKELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWN 2type2 --ASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL-RTKSQK 4type4 --PSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRS-RTPRGL 7type7 --ASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPK 5type5 ---TNSIGHNPPHWGAERPFYNHLGGNQVSK--------EMKRMGFEDPKDKN--AQESA 6type6 ---ANSMEGLMPRWVPDRAFS----RTKDSK--------AFRQMGIDDSSKDNRGTQDAL 1type1 CYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKR-------RALRTASEKLRNRSSFSTNVV 8type8 ---NSGATFTEGSWSPELPFDN-IVGKQNTLA-------ALTRNSINLLPNHLAQALHVQ 3type3 --SKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVD 9type9 FDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEE 10type10 -NLFKYSIKLTEKLNMVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLS 2type2 KR----------------------FEEELNERMIQAIDGINAQKQWL-KSEDIQRISLLF 4type4 DD----------------------ELDTGDAKFFQVIEQLNSQKQWK-QSKDFNPLTLYF 7type7 GRS---------------------EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIF 5type5 N-----------------------PEDEVDEFLGRAIDARSIDRLRS---EHVRKFLLTF 6type6 N-----------------------PEDEVDEFLSRAIDARSIDQLRK---DHVRRFLLTF 1type1 YTT---------------------PGTRVNRYISRLLEAR-QTELEM---ADLNFFTLKY 8type8 S-----------------------GPEEINKRIEHTIDLRSGDKLRR---EHIKPFSLMF 3type3 ASE---------------------DEHELNQLLNEALLERESAQVVK--KRNTFLLSMRF 9type9 KLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFF 10type10 HQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQ . 2type2 YNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFIL 4type4 REKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLIL 7type7 LEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVL 5type5 REPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVV 6type6 QREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITV 1type1 KHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACV 8type8 KDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSAL 3type3 MDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILT 9type9 KPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLST 10type10 NDPSFEVHYRSLSLKPSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQ : . 2type2 FVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSD 4type4 FVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPT 7type7 GLCFATKFSRCCPARG----TLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPF 5type5 FVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGC 6type6 LICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSC 1type1 LYLHIT-RVQCFPGCLTIQIR---------TVLCIFIVVLIYSVAQG--------CVVGC 8type8 VLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILN-----------I 3type3 ICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVD--------MLSC 9type9 TCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWL 10type10 RKAMHLKCARFLEEDAHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEE 2type2 SEETIPPTANTTNTSFSAS------------------------------NNQVAILRAQN 4type4 SSDCP---FQAPNVSSMIS------------------------------NLSWELPGSLP 7type7 QVPELP---VGNETGLLAA------------------------------SSKTRALCEP- 5type5 LAQEHNISASQVNACHVAESA---------------------VNYSLGDEQGFCGSPWPN 6type6 AARMLNLTPADITACHLQQ-----------------------LNYSLGLDAPLCEGTMPT 1type1 LPWAWSSKPNSSLVVLSSG------------------------------GQRTALPTLP- 8type8 LWCDFDKSIPLKNLTFNSS-----------------------------------AVFTDI 3type3 LQYYTGPSNATAGMETEGS----------------------------------------C 9type9 PRHCIGAILVSLPALAVYS--------------------------------HVTSEYETN 10type10 KLILSNSEIPETSAFFPENRSPEEIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILE 2type2 LFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT-----------HA 4type4 LISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHS-----------HA 7type7 ---LPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLS-----------PC 5type5 CNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEV-P-----GVTLFDN 6type6 CSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGP-----PATIFDN 1type1 CESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLEL-------------- 8type8 CSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTET-------------- 3type3 LENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRF 9type9 IHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP----DSSVLT 10type10 IVILPLAHHFLALGENDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWS :. :. : : 2type2 HVLGDYSQVLFE-----------RPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLD 4type4 WLSECLIVRLYLGPL------DSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLD 7type7 WQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLD 5type5 ADLLVTANAIDFFNNGTS--QCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLD 6type6 YDLLLGVHGLASSNETFDGLDCPAAG-RVALKYMTPVILLVFALALYLHAQQVESTARLD 1type1 -----------------SGYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLD 8type8 --------VYAGLFLRYDNLNHSGED-FLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLD 3type3 REHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTL 9type9 SPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLH 10type10 QTFESATFYSLKGEVCFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFH . . : : 2type2 FLWKNKFKKEREEIETMENLNRV----------------------------LLENVLPAH 4type4 FLWKKKLRQEREETETMENLTRL----------------------------LLENVLPAH 7type7 CLWKKKFKKEHEEFETMENVNRL----------------------------LLENVLPAH 5type5 FLWKLQATEEKEEMEELQAYNRR----------------------------LLHNILPKD 6type6 FLWKLQATGEKEEMEELQAYNRR----------------------------LLHNILPKD 1type1 YLWAAQAEEEREDMEKVKLDNRR----------------------------ILFNLLPAH 8type8 FLWRVQAKEEINEMKELREHNEN----------------------------MLRNILPSH 3type3 FLWKIEVHDQKERVYEMRRWNEA----------------------------LVTNMLPEH 9type9 YHGDVEADLHRTKIQSMRDQADW----------------------------LLRNIIPYH 10type10 YVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALET : : * 2type2 VAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADF 4type4 VAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADF 7type7 VAAHFIG-DKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADF 5type5 VAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADF 6type6 VAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADF 1type1 VAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADF 8type8 VARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADF 3type3 VARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDF 9type9 VAEQLKVSQTYS-----KNHDSGGVIFASIVNFSEFYEEN--YEGGKECYRVLNELIGDF 10type10 QNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFN . : * * . : * * : * : 2type2 DDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE-------HSQEPERQYMHIGTMVEF 4type4 DELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQD-------AQQDAERSCSHLGTMVEF 7type7 DELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHE-------N-QELERQHAHIGVMVEF 5type5 DEIISEDRFRQLEKIKTIGSTYMAASGLNDST----------YDKVGK---THIKALADF 6type6 DEIISEERFRQLEKIKTIGSTYMAASGLNAST----------YDQVGR---SHITALADY 1type1 DELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS----------GTKAKKSISSHLSTLADF 8type8 DELLGEDRFQDIEKIKTIGSTYMAVSGLSPEK----------QQCEDK--WGHLCALADF 3type3 DSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADF 9type9 DELLSKPDYSSIEKIKTIGATYMAASGLNTAQ-----------AQDGSHPQEHLQILFEF 10type10 KLIMGHLDLAIELGSRALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWEL . :: . ::: : : : : 2type2 AFALVGKLDAINK-HSFNDFKLRVGINHG------------------PVIAGVIGAQKPQ 4type4 AVALGSKLDVINK-HSFNNFRLRVGLNHG------------------PVVAGVIGAQKPQ 7type7 SIALMSKLDGINR-HSFNSFRLRVGINHG------------------PVIAGVIGARKPQ 5type5 AMKLMDQMKYINE-HSFNNFQMKIGLNIG------------------PVVAGVIGARKPQ 6type6 AMRLMEQMKHINE-HSFNNFQMKIGLNMG------------------PVVAGVIGARKPQ 1type1 AIEMFDVLDEINY-QSYNDFVLRVGINVG------------------PVVAGVIGARRPQ 8type8 SLALTESIQEINK-HSFNNFELRIGISHG------------------SVVAGVIGAKKPQ 3type3 ALAMKDTLTNINN-QSFNNFMLRIGMNKG------------------GVLAGVIGARKPH 9type9 AKEMMRVVDDFNNNMLWFNFKLRVGFNHG------------------PLTAGVIGTTKLL 10type10 SVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSS : . .: : *: . :*:: 2type2 YDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGK--------- 4type4 YDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGK--------- 7type7 YDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGK--------- 5type5 YDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGK--------- 6type6 YDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGK--------- 1type1 YDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGK--------- 8type8 YDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQE----- 3type3 YDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGK--------- 9type9 YDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGK--------- 10type10 VAIWYARLQEWDNFYKFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENA ** :: ..: . . . : .* : 2type2 ----GDLKTYFVNTEMSRSLSQSNVAS--------------------------------- 4type4 ----GQLCTYFLNTDLTRTGPPSATLG--------------------------------- 7type7 ----GELRTYFVCTDTAKFQGLGLN----------------------------------- 5type5 ----GEMMTYFLNGGPPLS----------------------------------------- 6type6 ----GEMTTYFLNGGPSS------------------------------------------ 1type1 ----GEMLTYFLEGRTDGNGSQIRS-------------LGLDRKMCPFGRAGLQGRRPPV 8type8 ----GKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNT 3type3 ----GELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS----------------------- 9type9 ----GQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDK 10type10 QASGEELLKNLENLVAQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQG .: . : 2type2 ------------------------------------------------------------ 4type4 ------------------------------------------------------------ 7type7 ------------------------------------------------------------ 5type5 ------------------------------------------------------------ 6type6 ------------------------------------------------------------ 1type1 CPMPGVSVRAGLPPHSPGQYLPSAAAGKEA------------------------------ 8type8 GIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP--------------------------- 3type3 ------------------------------------------------------------ 9type9 TSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEEANELTKLNVS 10type10 NILEKCWLNMNKESWYSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANT 2type2 ----- 4type4 ----- 7type7 ----- 5type5 ----- 6type6 ----- 1type1 ----- 8type8 ----- 3type3 ----- 9type9 KSV-- 10type10 VDNHF