Sequence alignment of several PH domains
 

Dynamin	513	RKGWLTINNI	G.......IMKGG	SK.EYWFVLT	AE	NLSWY	KDDEE..... .........KE	KKYMLS
PLCd1	23	LKGSQLLKVK	S.........SSW	RR.ERFYKLQ	ED	CKTIW	QESRKVMRTP ESQLFSIEDIQ	EVRMGH
PLCb2	22	SQGERFIKWD	D.........ETT	VA.SPV.ILR	VD	PKGYY	LYWTYQS..K EMEFLDITSIR	DTRFGF
Pleckstrinl	7	REGYLVKKG.	........SVFNT	WKPMWVVLL.	ED	GIEFY	KKKSDNS... ...........	PKGMIP
bSpectrin	2199	MEGFLNRKHE	WEAHNKK.ASSRS	WH.NVYCVIN	NQ	EMGFY	KDAKSAASGI PY........H	SEVPVS
Btk	6	LESIFLKRSQ	Q.....KKKTSPL	NFKKRLFLLT	VH	KLSYY	EYDFERGRR. ....GS..KKG	SIDVEK
		b1	Loop	b2	L	b3	Loop	b4

 
 
 

Dynamin	558	VDN	LKLRDVE	KGFMS	SKHIF... ALF	NTE..QR NVYKDY	RQLELAC	ET	QEEVDSWKASFLRAG
PLCd1	80	RT.	EGLEKFA	RDVPE	DRCFSI.. .VF	K...... ...DQR	NTLDLIA	PS	PADAQHWVLGLHKII
PLCb2	73	AKi	DVFNMii	DNSFL	LKTLTV.. .VS	G...... ...PDM	iFHNFVS	YK	ENVGKAWAEDVLALV
Pleckstrinl	51	LKG	STLTSPC	QDFGK	RMFVF... KIT	T...... ...TKW	QDHFFQA	AF	LEERDAWVRDINKAI
bSpectrin	2256	LKE	.AICEVA	LDYKK	KKHVF... KLR	L...... ....SD	GNEYFQA	KD	DEEMNTWIQAISSA.
Btk	61	ITC	VETVVPE	KNPiI	IERFPY.. .PF	QVV.... ...YDE	GPLYVFS	PT	EELRKRWIHQLKNVI
		L	b5	Loop	b6	Loop	b7	L	Alpha

• Residues of PLC-b ₁ and b -spectrin PH domains that specifically interact with ligand are in magenta.
• R ® C mutation in Btk (Bruton's tyrosine kinase) found in Xid (agammaglobulinaemic) mice is in blue.
• i indicates an insertion.