Publications

Kroll F, Donnelly J, Özcan GG, Mackay E, Rihel J* (2025). Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes. eLife 13:RP96839.

Kempthorne L, Vaizoglu D, Cammack AJ, et al., Rihel J and Isaacs AM (2025). Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo. Nature Communications 16:495.

Suppermpool A, Lyons DG, Broom E, Rihel J* (2024). Sleep pressure modulates single-neuron synapse dynamics in zebrafish. Nature 629, 639–645.

Özcan GG, Lim S, Canning T, Tirathdas L, Donnelly J, Kundu T, Rihel J* (2024). Genetic and chemical disruption of Amyloid Precursor Protein processing impairs zebrafish sleep maintenance. iScience 27, 108870.

Benoit E, Lyons DG, Rihel J* (2023). Noradrenergic Tone is Not Required for Neuronal Activity-Induced Rebound Sleep in Zebrafish. J Comp Physiol B.

Barlow IL, Mackay E, Wheater E, Goel A, Lim S, Zimmerman S, Woods I, Prober DA, Rihel J* (2023). The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation. eLife 12:RP87521.

Kroll F, Powell GT, Ghosh M, Antinucci P, Hearn TJ, Tunbak H, Lim S, Dennis HW, Fernandez JM, Hoffman EJ, Whitmore D, Dreosti E, Wilson SW and Rihel J* (2021). A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. eLife: e59683.

Rihel J (2020). Sleep Across the Animal Kingdom. In: Sleep Science, Oxford University Press, pages 15–31.

Özcan GG, Lim S, Leighton PLA, Allison WT, Rihel J* (2020). Sleep is bi-directionally modified by amyloid beta oligomers. eLife Jul 14;9:e53995. Paper won Sleep Research Society Young Investigator Award to Dr Özcan.

Lyons DG and Rihel J* (2020). Sleep circuits and physiology in non-mammalian systems. Current Opinion in Physiology.

Ghosh M and Rihel J* (2020). Hierarchical compression reveals sub-second to day-long structure in larval zebrafish behaviour. eNeuro.

Dreosti E, Hoffman EJ, and Rihel J (2020). Modelling autism spectrum disorders in zebrafish. In: Gerlai RT (ed). Behavioral and Neural Genetics of Zebrafish. Elsevier Inc./Academic Press: pp. 451–471.

Shibata-Germanos S, Goodman JR, Grieg A, Trivedi C, Lashley T, Benson BC, Foti SC, Faro A, Castellan R, Correra R, Barber M, Ruhrberg C, Weller RO, Iliff JJ, Hawkins TA, and Rihel J* (2019). Conservation of a vertebrate meningeal phagocyte with structural and functional characteristics of lymphatic endothelial cells. Acta Neuropathologica.

Reichert S, Pavon Arocas O, Rihel J* (2019). The neuropeptide Galanin is required for homeostatic rebound sleep following increased neuronal activity. Neuron 104(2):370–384.

Ashlin TG, Blunsom NJ, Ghosh M, Cockcroft S* and Rihel J* (2018). Pitpnc1a regulates zebrafish sleep and wake behavior through modulation of Insulin-like Growth Factor signaling. Cell Reports 24(6), 1389–1396.

Rihel J (2018). Copper on the Brain. Nature Chemical Biology 14(7):638–639.

Singh C, Rihel J, and Prober DA (2017). Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current Biology.

Shams S, Rihel J, Ortiz JG, and Gerlai R (2017). The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium. Neuroscience and Biobehavioral Reviews.

Chen S, Reichert S, Singh C, Oikonomou G, Rihel J*, and Prober DA* (2017). Light-dependent regulation of sleep/wake states by prokineticin 2 in zebrafish. Neuron.

van Lessen M, Shibata-Germanos S, van Impel A, Hawkins TA, Rihel J, and Schulte-Merker S (2017). Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development. eLife.

Barlow IL and Rihel J (2017). Zebrafish sleep: from geneZZZ to neuronZZZ. Current Opinion in Neurobiology.

Naumann E, Fitzgerald JE, Dunn TW, Rihel J, Sompolinsky H, and Engert F (2016). From Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response. Cell 167(4):947–960.

Tuschl K, Meyer E, Valdivia LE, Zhao N, Dadswell C, Abdul-Sada A, et al. (2016). Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nature Communications 7:11601.

Chiu CN*, Rihel J*, Lee DA, Singh C, Mosser EA, Chen S, Sapin S, Engle J, Niles BJ, Montz CJ, Chakravarthy S, Salehi-Ashtiani K, Vidal M, Schier AF, Prober DA (2016). A zebrafish genetic screen identifies neuromedin U as a regulator of sleep/wake states. Neuron 89(4):842–856. *co-first author

Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJF, Wilson SW, Rihel J*, State MW*, Giraldez AJ* (2016). Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron.

Davies WIL, Tamai TK, Zheng L, Fu JK, Rihel J, Foster RG, Whitmore D, and Hankins MW (2015). An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome Research 25:1–4.

Rihel J* and Bendor D (2015). Flies Sleep on It, or Fuhgeddaboudit! Cell 161, 1498–1500.

Rihel J* and Ghosh M (2015). Zebrafish. In: Drug Discovery and Evaluation: Pharmacological Assays, F.J. Hock, ed. Springer Berlin Heidelberg.

O'Leary LA (2014). Orexin and melanin-concentrating hormone neurons: a hypothalamic interface for sleep and feeding regulation. Bioscience Horizons 7: hzu008. Supervisor: Rihel J

Özcan GG and Rihel J* (2014). A Drosophila Circuit feels the (Sleep) Pressure. Neuron 81(4):720–722.

Rihel J* and Schier AF (2013). Sites of action of sleep and wake drugs: insights from model organisms. Current Opinion in Neurobiology 23(5):831–840.

Rihel J* and Schier AF (2012). Behavioral screening for neuroactive drugs in zebrafish. Developmental Neurobiology 72(3):373–385.

Rihel J*, Prober DA, and Schier AF (2010). Chapter 11 — Monitoring sleep and arousal in zebrafish. Methods in Cell Biology 100:281–294.

Rihel J*, Prober DA*, Arvanites A, Lam K, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, and Schier AF (2010). Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 327(5963):348–351. *equal contribution

Emran F, Rihel J, Adolph AR, Dowling JE (2010). Larval zebrafish lose vision at night. PNAS 107(13):6034–6039.

Prober DA, Zimmerman S, Myers BR, McDermott BM Jr., Kim SH, Caron S, Rihel J, Solnica-Krezel L, Julius D, Hudspeth AJ, and Schier AF (2008). Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neuroscience 28(40):10102–10110.

Emran F, Rihel J, and Dowling JE (2008). A behavioral assay to measure responsiveness of zebrafish to changes in light intensities. J of Visualized Experiments 19.

Emran F, Rihel J, Adolph AR, Wong KY, Kraves S, and Dowling JE (2007). OFF ganglion cells cannot drive the optokinetic reflex in zebrafish. PNAS 104(48):19126–19131.

Prober D, Rihel J, Onah AA, Sung RJ, Schier AF (2006). Hypocretin/orexin overexpression generates a zebrafish genetic model of insomnia. J Neuroscience 26(51):13400–13410.

Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier AF (2006). Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312(5770):75–79.

Tietjen I, Rihel J, Dulac CG (2005). Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium. International Journal of Developmental Biology 49(2–3):201–207.

Tietjen I*, Rihel JM*, Cao Y*, Koentges G, Zakhary L, Dulac C (2003). Single cell transcriptional analysis of neuronal progenitors. Neuron 38:161–175. *equal contribution

Bao S*, Rihel J*, Bjes E, Price JL (2001). The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. J Neuroscience 21(18):7117–7126. *equal contribution