Selected Publications
Bettedi, L., Yan, A., Schuster, E., Alic, N., Foukas, L.C. (2020) Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue. Sci Rep 10(1):3418.
Araiz, C., Yan, A., Bettedi, L., Samuelson, I., Vitrue, S., McGavigan, A.K., Dani, C., Vidal-Puig, A. and Foukas, L.C. (2019) Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nature Commun 10, 1546-1560.
Bettedi, L., and Foukas, L.C. (2017) Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing. Biogerontology. 18, 913-929.
Foukas, L.C. , Bilanges, B., Bettedi, L, Pearce, W, Ali, K, Sancho, S. Withers, D.J., and Vanhaesebroeck, B. (2013) Long-term p110alpha PI3K inactivation exerts a beneficial effect on metabolism. EMBO Mol Med 5, 563-571.
Foukas, L.C., Berenjeno, I.M., Gray, A., Khwaja, A., and Vanhaesebroeck, B. (2010) Activity of any class IA PI3K isoform can sustain cell proliferation and survival. Proc Natl Acad Sci USA 107, 11381-13816.
Foukas, L.C. and Withers, D.J. (2010) Phosphoinositide signalling pathways in metabolic regulation. Curr Top Microbiol Immunol. 346, 115-141.
Foukas, L.C., Claret, M., Pearce, W., Okkenhaug, K., Meek, S., Peskett, E., Sancho, S., Smith, A.J.H., Withers D.J., and Vanhaesebroeck, B. (2006) Key role for the p110alpha phosphoinositide 3-kinase in growth and metabolic regulation. Nature 441, 366-370.