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UCL Ear Institute
332 Gray's Inn Rd
London, WC1X 8EE


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Lesica Lab

Recent Papers

Inhibitory control
of correlations

Periodotopy in
the gerbil IC

Ultrasonic frequencies
in the mouse IC

Independent coding of
speech in the IC







How does brain activity represent the information from the senses?

Answering this question, i.e. cracking the neural code or reverse-engineering the brain, has been cited as one of the grand research challenges of the 21st century.

Understanding the meaning of our brain's activity is essential not only for basic science, but also for developing therapeutic and prosthetic approaches to replacing brain function that has been lost to trauma or disease, as well ascreating intelligent artificial systems for tasks such as speech recogntition.



Traditionally, researchers have investigated the brain by studying one neuron at a time. While this work has provided invaluable insight into the function of individual neurons, we still know very little about how populations of neurons (our brain has billions of them, with trillions of connections between them!) interact to form a coherent representation of the outside world.

In our research, we take advantage of recent technological advances to observe the activity of many neurons simultaneously, and try to understand the strategies they are using to communicate with each other.


Our main focus is the auditory system, specifically the inferior colliculus, the so-called 'hub' of the mammalian system. We also work with other researchers to study the visual system, and develop computational models to consolidate our findings and test new ideas. More detailed information about our work can be found through the above links.

Our work is supported by the Wellcome Trust and the German Research Foundation (Deutsche Forschungsgemeinschaft).