

My research focuses on the plasticity and recovery of language networks
following surgical intervention for epilepsy. Such surgery aims to
resect epileptogenic tissue in order to reduce seizure frequency and
severity in those who don't respond to traditional drug therapy.
Post-surgical deficits in various cognitive domains are common, in
particular language and memory. How these impairments change over time
is poorly understood. We know that higher cognitive functions arise as
a result of the efficient interaction of multiple cortical areas. As
such, the investigation of disruption and dysfunction of these domains
must take a network approach in order to fully appreciate how damage
impacts these circuits. In the paediatric brain, functional networks
show a greater degree of plasticity. Understanding the temporal
dynamics of network plasticity, and how this corresponds to behavioural
and cognitive function will allow us to better understand how damage
shapes the developing brain.
I am conducting a long-term MRI follow up study of paediatric epilepsy surgery patients from Great Ormond Street Hospital, using both structural and functional methods of network analysis. Dynamic causal modelling is a method of interrogating the effective connectivity between cortical areas, allowing inference about temporal dynamics and connection strength at a neuronal level. I'm pairing this approach with diffusion tensor imaging to reconstruct and analyse the integrity of white matter networks, to provide a comprehensive understanding of the long-term plastic changes of the language system.
I work in the Developmental Cognitive Neuroscience Unit in the Institute of Child Health. My research is supported by a Child Health Research Appeal Trust studentship.
I am supervised by Dr Torsten Baldeweg (Developmental Cognitive Neuroscience Unit) and Dr Jon Clayden (Imaging and Biophysics Unit).
We are currently recruiting for healthy control subjects between the ages of 16-22. The study involves an MRI scan, and neuropsychological assessment. If you're interested in taking part in our research, please contact me for more information.
MSc
Neuroscience - Kings College London
BSc
Psychology - Royal Holloway, University of London
Centre for Developmental Cognitive Neuroscience
Developmental
Cognitive Neuroscience Unit
UCL
Institute of Child Health
30
Guilford Street
London
WC1N
1EH
+44(0)2079052607